Das Addenbrooke’s Cognitive Examination III (ACE-III) ist ein frei zugängliches neurokognitives Messinstrument mit sehr hoher diagnostischer Qualität, das dem Mini-Mental-Status-Test (MMST) überlegen ist. Ein adäquates Screening in der stationären und ambulanten Patientenversorgung ist eine der Hauptvoraussetzungen für die optimale Therapie von Demenzerkrankungen. Zielsetzung: Altersbedingte Erkrankungen wie Demenz nehmen eine immer zentralere Rolle in unserer alternden Gesellschaft ein und tragen maßgeblich zur globalen Krankheitslast bei. Neurocognitive disorders, neuropsychological test, translation and cultural adaptation, Addenbrooke's Cognitive Examination III Ĭonclusion: The German ACE-III translation in its current form is generally applicable and can be utilized for clinical and scientific purposes. When evaluating survey items assessing the applic ability of the individual 19 subtests of the ACE-III, all of them (100%) were rated as applicable with a median rating of 4.5. Results: Nineteen of the 20 practitioners (95.0%) rated the German ACE-III translation as overall applicable. This revised German consensus translation was subsequently evaluated for clinical applicability on a 5-point scale (0 – not applicable 5 – applicable without any restrictions) by 20 practitioners experienced in the field of neuropsychological testing, using an anonymized, paper-based 22-item survey. After comparison, the German consensus translation was revised with emphasis on the identified differences between the English original version and the English translated version. Four separate English-German translations were compiled into one German consensus translation, which was then translated back into English and compared to the original English version. Methods: The translation and cultural adaptation were performed in accordance with the “Principles of Good Practice for the Translation and Cultural Adaptation Process for Patient-Reported Outcomes (PRO) Measures” from the International Society for Pharmacoeconomics and Outcome Research (ISPOR) (Wild et al. Our aim was to perform a guideline-conform English-German translation and cultural adaptation of the ACE-III in order to enable implementation in German-speaking countries. The Addenbrooke’s Cognitive Examination III (ACE-III) is an open-source neuropsychological test with superior diagnostic quality in comparison to the Mini-Mental State Examination (MMSE). Adequate screening in the primary care setting is critical for early detection and proper management. Objective: Age-related disorders, such as dementia, significantly contribute to the global burden of disease. Vision and Motor System Research Group, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany Department for Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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